Former Senator David Leyonhjelm has lost his bid to overturn a ruling that he defamed Greens Senator Sarah Hanson-Young, meaning he will have to pay $120,000 in compensation.

The Federal Court found Mr Leyonhjelm defamed Senator Hanson-Young by suggesting she was a misandrist and a hypocrite in Parliament and in media interviews in 2018.

Senator Hanson-Young was awarded $120,000 in compensation, which she pledged would go to charity.

But Mr Leyonhjelm unsuccessfully appealed that decision to the Full Court of the Federal Court.

More to come.